CD164
Description
The CD164 (CD164 molecule) is a protein-coding gene located on chromosome 6.
CD164, also known as sialomucin core protein 24 or endolyn, is a protein encoded by the CD164 gene in humans. It functions as a cell adhesion molecule. Sialomucins are a diverse group of secreted or membrane-associated mucins that play crucial roles in the body, acting as both cytoprotective/antiadhesive agents and adhesion receptors. CD164 is a type I integral transmembrane sialomucin that acts as an adhesion receptor.
CD164 is a sialomucin that plays a key role in hematopoiesis by facilitating the adhesion of CD34(+) cells to the stroma and negatively regulating CD34(+)CD38(lo/-) cell proliferation. It modulates the migration of umbilical cord blood CD133+ cells through the CXCL12/CXCR4 axis. CD164 may be involved in prostate cancer metastasis and bone marrow infiltration by cancer cells. It promotes myogenesis by enhancing CXCR4-dependent cell motility, positively regulates myoblast migration, and promotes myoblast fusion into myotubes. CD164 forms a homodimer (isoform 4) and interacts with CXCR4.
CD164 is also known as DFNA66, MGC-24, MGC-24v, MUC-24, endolyn.
