CD101

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Description

The CD101 (CD101 molecule) is a protein-coding gene located on chromosome 1.

CD101, also known as Immunoglobulin superfamily member 2 (IGSF2), is a human gene.

CD101 inhibits T-cell proliferation by multiple mechanisms, including:

• Blocking CD3-induced signaling pathways, inhibiting tyrosine kinases required for IL2 production and cellular proliferation.
• Inhibiting phospholipase C-gamma-1 (PLCG1) phosphorylation, thereby preventing CD3-induced changes in intracellular calcium levels.
• Preventing nuclear translocation of nuclear factor of activated T-cells (NFAT) to the nucleus.
• Promoting IL10 secretion by cutaneous dendritic cells, further inhibiting T-cell proliferation.

CD101 may also serve as a marker for CD4(+) CD56(+) leukemic tumor cells. These functions are supported by multiple studies.

CD101 is also known as EWI-101, IGSF2, V7.

Associated Diseases

• type 2 diabetes mellitus
• type 1 diabetes mellitus
• nonimmune chronic idiopathic neutropenia of adults
• X-linked severe congenital neutropenia
• neutropenia, severe congenital, 2, autosomal dominant
• neutropenia-monocytopenia-deafness syndrome
• autosomal recessive severe congenital neutropenia due to CSF3R deficiency