CCT7
Description
The CCT7 (chaperonin containing TCP1 subunit 7) is a protein-coding gene located on chromosome 2.
CCT7 is a gene that encodes a molecular chaperone, a protein that helps other proteins fold correctly. CCT7 is part of the TRiC complex, which consists of two rings of eight different proteins. Unfolded proteins enter the center of the complex and are folded in an energy-dependent process. TRiC is involved in the folding of various proteins, including actin and tubulin. Different forms of the CCT7 protein are produced through alternative splicing, but only two have been studied in detail. CCT7 interacts with the protein PPP4C.
CCT7 is a component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. TRiC mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin.
CCT7 is also known as CCTETA, CCTH, NIP7-1, TCP1ETA.
Associated Diseases
- low grade glioma
- acute kidney failure
- cancer
- type 1 diabetes mellitus
- breast cancer
- Huntington disease
- Alzheimer disease
