CCT6B
Description
The CCT6B (chaperonin containing TCP1 subunit 6B) is a protein-coding gene located on chromosome 17.
CCT6B gene encodes a protein that is part of the TRiC complex, a molecular chaperone responsible for folding proteins. TRiC consists of two stacked rings with eight different proteins each. This complex helps unfold proteins enter its central cavity and fold them in an ATP-dependent manner. This process is crucial for the proper folding of various proteins, including actin and tubulin. While alternate versions of CCT6B have been found, their functions are not fully understood.
CCT6B is a subunit of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that helps proteins fold correctly by utilizing ATP hydrolysis.
CCT6B is also known as CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303.
Associated Diseases
- ovarian cancer
- endometrial cancer
- urinary bladder cancer
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 24
- spermatogenic failure 51
- spermatogenic failure 72
- spermatogenic failure 46
- spermatogenic failure 27
- spermatogenic failure 18
- spermatogenic failure 43
