CCT3
Description
The CCT3 (chaperonin containing TCP1 subunit 3) is a protein-coding gene located on chromosome 1.
CCT3 is a human gene that encodes a molecular chaperone belonging to the TRiC complex. This complex comprises two stacked rings, each consisting of eight distinct proteins. Unfolded polypeptides enter the central cavity of the complex, where they are folded in an ATP-dependent manner. The TRiC complex folds various proteins, including actin and tubulin. Different isoforms of CCT3 are generated by alternative splicing. CCT3 interacts with PPP4C.
CCT3 is part of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that helps fold proteins using energy from ATP. This complex is involved in folding WRAP53/TCAB1, which is essential for maintaining telomeres. Additionally, CCT3 may contribute to the formation of BBSome, a complex crucial for ciliogenesis by regulating the transport of vesicles to cilia. Evidence suggests that CCT3 plays a role in the folding of actin and tubulin.
CCT3 is also known as CCT-gamma, CCTG, PIG48, TCP-1-gamma, TRIC5.
