CCRL2
Description
The CCRL2 (C-C motif chemokine receptor like 2) is a protein-coding gene located on chromosome 3.
CCRL2, short for C-C chemokine receptor-like 2, is a protein found in humans and encoded by the CCRL2 gene. It's a seven-transmembrane protein closely related to CCR1, another chemokine receptor. Chemokine receptors are important for guiding immune cells to sites of inflammation. CCRL2 is highly expressed in neutrophils (a type of white blood cell) and monocytes (a type of immune cell that can become macrophages). Its expression increases when neutrophils are activated and when monocytes transform into macrophages. While its exact function is unknown, CCRL2 has been found to act as a receptor for the chemokine chemerin. It's located near a cluster of chemokine receptor genes on the chromosome.
CCRL2 binds to CCL19 and chemerin/RARRES2, but unlike typical signaling receptors, it doesn't directly trigger cellular responses. Instead, it influences immune reactions by capturing and removing CCL19 from the environment or by presenting the RARRES2 ligand to CMKLR1, a receptor that does send signals. This process is crucial for the development of Th2 responses, a specific type of immune response.
CCRL2 is also known as ACKR5, CKRX, CRAM, CRAM-A, CRAM-B, HCR.
