CCR9
Description
The CCR9 (C-C motif chemokine receptor 9) is a protein-coding gene located on chromosome 3.
C-C chemokine receptor type 9 (CCR9) is a protein encoded by the CCR9 gene in humans. This gene is located within the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been identified. CCR9 is classified as CDw199 (cluster of differentiation w199). The protein encoded by CCR9 belongs to the beta chemokine receptor family and is a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors, such as CCR9 and its binding agonist, play a crucial role in regulating thymocyte migration and maturation in both normal and inflammatory conditions. The specific agonist or ligand that binds CCR9 is CCL25, also known as TECK in some literature. The effects of chemokines binding to their specific receptors are generally dependent on the structural placement of the N terminal cysteine(s) amino acids. Receptors are categorized into four family groups: CXC, CC, C, and CX3C. Due to the presence of two adjacent cysteines, CCR9 is classified as a C-C family receptor.
CCR9 is also known as CC-CKR-9, CDw199, GPR-9-6, GPR28.
Associated Diseases
- ovarian cancer
- Bardet-Biedl syndrome
- Hirschsprung disease
- COVID-19
- type 2 diabetes mellitus
- Okt4 epitope deficiency
- type 1 diabetes mellitus
- combined immunodeficiency with skin granulomas
- diabetes mellitus, transient neonatal, 2
- 22q11.2 deletion syndrome
- immunodeficiency 19
- neutropenia, severe congenital, 2, autosomal dominant
