CCR7
Description
The CCR7 (C-C motif chemokine receptor 7) is a protein-coding gene located on chromosome 17.
CCR7 (C-C chemokine receptor type 7) is a protein that guides immune cells to immune organs like lymph nodes, thymus, and spleen. It is encoded by the CCR7 gene in humans. CCR7 binds to two chemokines: CCL19 (ELC) and CCL21. These chemokines have similar affinities for CCR7, but CCL19 can cause internalization of CCR7 and desensitize the cell to CCL19/CCL21 signals. CCR7 is a transmembrane protein with seven transmembrane domains, coupled with heterotrimeric G proteins, which transmit signals through various pathways. Its main function is to direct immune cells to immune organs by recognizing specific chemokines secreted by these tissues. CCR7 also plays a role in the development of T cells in the thymus and is expressed mainly on adaptive immune cells, including thymocytes, naive T and B cells, regulatory T cells, central memory lymphocytes, and dendritic cells.
CCR7 is also known as BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1.
Associated Diseases
- urinary bladder carcinoma
- pancreatic ductal adenocarcinoma
- adult T-cell leukemia/lymphoma
- skin squamous cell carcinoma
