CCNF
Description
The CCNF (cyclin F) is a protein-coding gene located on chromosome 16.
CCNF (Cyclin-F) is a human gene that encodes a protein involved in cell cycle regulation. It belongs to the cyclin family, which are important regulators of cell cycle transitions. CCNF is also a member of the F-box protein family, characterized by an F-box motif that interacts with other proteins. This protein is part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex, which plays a role in protein degradation. CCNF was first discovered in 1994 while experimenting with yeast. It was also identified independently as a new cyclin during the search for candidate genes for polycystic kidney.
CCNF, also known as F-box only protein 1, is a substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. This complex mediates the ubiquitination and subsequent proteasomal degradation of target proteins, playing a crucial role in regulating cell cycle progression and maintaining genome stability. The SCF(CCNF) complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle. CCNF mediates the degradation of various target proteins, including CP110, RRM2, CDC6, and CDH1. It inhibits centrosome reduplication by degrading CP110 during G2 phase, maintains a balanced pool of dNTPs by degrading RRM2 in G2, and suppresses DNA re-replication by degrading CDC6 in G2. CCNF also acts as an antagonist of the APC/C by degrading its substrate adapter CDH1, thereby regulating G1 progression and S phase entry. Additionally, CCNF may play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB. The CCF(CCNF) complex consists of CUL1, RBX1, SKP1, and CCNF. CCNF interacts with SKP1, CUL1, CCNB1, CCP110, MYBL2/BMYB, FZR1/CDH1, RRM2, and CDC6.
CCNF is also known as FBX1, FBXO1, FTDALS5.
