CCND1

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Description

The CCND1 gene, located on chromosome 11, encodes cyclin D1, a crucial protein involved in regulating the cell cycle. Cyclin D1 interacts with cyclin-dependent kinases (CDKs), forming complexes that control the transition from the G1 to S phase of the cell cycle. Proper regulation of CCND1 expression is essential for normal cell growth and development. However, dysregulation of CCND1 can lead to uncontrolled cell proliferation and contribute to the development of various cancers.

Associated Diseases

• Cancer (e.g., breast cancer, colorectal cancer, lymphoma, leukemia)
• Neurological disorders (e.g., Alzheimer‘s disease, Parkinson‘s disease)
• Immune system disorders (e.g., rheumatoid arthritis)

Did you know?

CCND1 gene expression is often upregulated in cancer cells, contributing to their uncontrolled growth.