CCNA1
Description
The CCNA1 (cyclin A1) is a protein-coding gene located on chromosome 13.
Cyclin-A1 is a protein that in humans is encoded by the CCNA1 gene. Cyclins, including Cyclin A1, are known for their cyclical abundance during the cell division cycle. These proteins act as activating subunits within enzymatic complexes alongside cyclin-dependent kinases (CDKs). The distinct expression and degradation patterns of different cyclins contribute to the precise timing of cell cycle events. Cyclin A1 has been shown to be expressed in testes and the brain, as well as in several leukemic cell lines. Its primary function is thought to be in the regulation of meiosis. Cyclin A1 interacts with both Cdk1 and Cdk2 kinases, leading to distinct kinase activities that appear in the S phase and G2 phase, respectively, and regulate separate cell cycle processes. Furthermore, Cyclin A1 has been found to bind to important cell cycle regulators such as Rb family proteins, transcription factor E2F1, and the Kip/Cip family of CDK-inhibitor proteins.
CCNA1 is also known as CT146.
Associated Diseases
- low grade glioma
- ovarian cancer
- endometrial cancer
- esophageal cancer
- urinary bladder cancer
- partial chromosome Y deletion
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 48
