CCL8
Description
The CCL8 (C-C motif chemokine ligand 8) is a protein-coding gene located on chromosome 17.
CCL8, also known as Monocyte Chemoattractant Protein 2 (MCP2), is a protein encoded by the CCL8 gene. It is a small cytokine belonging to the CC chemokine family. CCL8 is produced as a precursor of 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The CCL8 gene is located on chromosome 17q11.2. It attracts and activates various immune cells, including mast cells, eosinophils, basophils, monocytes, T cells, and NK cells. CCL8 binds to multiple cell surface receptors, including CCR1, CCR2B, CCR3, and CCR5. It is a potent inhibitor of HIV1 due to its high-affinity binding to CCR5, a major co-receptor for HIV1. CCL8 also contributes to breast cancer cell metastasis.
CCL8 is also known as HC14, MCP-2, MCP2, SCYA10, SCYA8.
