CCL3
Description
The CCL3 (C-C motif chemokine ligand 3) is a protein-coding gene located on chromosome 17.
CCL3, also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha), is a protein encoded by the CCL3 gene. It is a cytokine belonging to the CC chemokine family and plays a role in the acute inflammatory response by recruiting and activating polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4, and CCR5. CCL3 induces a fever that is not mediated through prostaglandin synthesis and cannot be inhibited by cyclooxygenase inhibitors. CCL3 interacts with CCL4 and attracts macrophages, monocytes, and neutrophils.
CCL3 is a chemokine with inflammatory and chemokinetic properties. It binds to the receptors CCR1, CCR4, and CCR5. CCL3 is a major HIV-suppressive factor produced by CD8+ T-cells. Recombinant CCL3 (MIP-1-alpha) inhibits the replication of various HIV strains, including HIV-1, HIV-2, and simian immunodeficiency virus (SIV) in a dose-dependent manner.
CCL3 is also known as G0S19-1, LD78, LD78ALPHA, MIP-1-alpha, MIP1A, SCI, SCYA3.
Associated Diseases
- cancer
- Miyoshi myopathy
- achalasia-alacrima syndrome
- nonpapillary renal cell carcinoma
- plasma fibronectin deficiency
- acute kidney failure
