CCL26

Description

The CCL26 (C-C motif chemokine ligand 26) is a protein-coding gene located on chromosome 7.

CCL26 (Chemokine (C-C motif) ligand 26) is a small cytokine belonging to the CC chemokine family. It is also known as Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. CCL26 is expressed by several tissues, including the heart, lung, and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4. CCL26 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3. The gene for CCL26 is located on human chromosome 7.

CCL26 is also known as IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1.

Associated Diseases

• hemoglobin D disease
• dominant beta-thalassemia
• hemoglobin E disease
• delta-beta-thalassemia
• hemoglobin C-beta-thalassemia syndrome
• alpha-thalassemia-myelodysplastic syndrome
• hemoglobin H disease
• hemoglobin E-beta-thalassemia syndrome