CCL22

Description

The CCL22 (C-C motif chemokine ligand 22) is a protein-coding gene located on chromosome 16.

CCL22, also known as C-C motif chemokine 22, is a protein produced by dendritic cells and macrophages in humans. It's encoded by the CCL22 gene, located on chromosome 16, alongside other chemokines, CX3CL1 and CCL17. CCL22 exerts its effects by binding to CCR4, a chemokine receptor on target cells.

CCL22 plays a crucial role in guiding activated T-cells to inflammation sites, influencing various aspects of their activity. It attracts monocytes, dendritic cells, and natural killer cells. While weakly attracting freshly activated T-cells, CCL22 strongly attracts chronically activated T-cells. Interestingly, it does not attract neutrophils, eosinophils, or resting T-cells. This attraction is mediated through binding to the CCR4 receptor. Notably, processed forms MDC(3-69), MDC(5-69), and MDC(7-69) are not considered active.

CCL22 is also known as A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing