CCL20

CCL20: A Key Player in Immune Cell Recruitment and Inflammation

Description

CCL20, also known as macrophage inflammatory protein-3alpha (MIP-3alpha), is a chemokine that plays a crucial role in the recruitment and activation of immune cells, particularly monocytes, dendritic cells, and T cells. It is produced by various cell types, including macrophages, endothelial cells, fibroblasts, and epithelial cells, in response to inflammatory stimuli.

Associated Diseases

CCL20 dysregulation has been implicated in several diseases characterized by chronic inflammation, including:

Rheumatoid arthritis
Inflammatory bowel disease (IBD)
Crohn's disease
Psoriasis
Atopic dermatitis
Asthma
Multiple sclerosis

Did you Know ?

CCL20 levels are significantly increased in the synovial fluid of patients with rheumatoid arthritis compared to healthy individuals. This elevated CCL20 concentration correlates with the severity of joint inflammation and destruction.

WES Whole Exome Sequencing