CCL19

Description

The CCL19 (C-C motif chemokine ligand 19) is a protein-coding gene located on chromosome 9.

CCL19, encoded by the CCL19 gene on chromosome 9, is a protein belonging to the CC cytokine family. These cytokines play a crucial role in immune regulation and inflammation. CCL19 contributes to normal lymphocyte circulation and homing, and is essential for T-cell trafficking in the thymus, as well as T and B cell migration to secondary lymphoid organs. Its specific binding partner is the chemokine receptor CCR7. CCL19 is expressed abundantly in the thymus and lymph nodes, with moderate levels in the trachea and colon, and low levels in the stomach, small intestine, lung, kidney, and spleen.

CCL19 plays a vital role in immune responses, including inflammation and lymphocyte circulation. It directs the movement of T cells within the thymus and facilitates the migration of both T and B cells to secondary lymphoid organs. CCL19 achieves this by specifically binding to the chemokine receptor CCR7. Studies show that recombinant CCL19 effectively attracts T cells and B cells, but not granulocytes or monocytes. Furthermore, CCL19 interacts with the atypical chemokine receptor ACKR4, leading to the recruitment of beta-arrestin proteins (ARRB1/2) to ACKR4.

CCL19 is also known as CKb11, ELC, MIP-3b, MIP3B, SCYA19.

Associated Diseases

WES Whole Exome Sequencing