CCL16
Description
The CCL16 (C-C motif chemokine ligand 16) is a protein-coding gene located on chromosome 17.
CCL16, also known as Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1), is a small cytokine belonging to the CC chemokine family. It is expressed by the liver, thymus, and spleen, and attracts monocytes and lymphocytes. CCL16 expression in monocytes can be significantly increased by IL-10, IFN-γ, and bacterial lipopolysaccharide. Its gene is located on chromosome 17, among a cluster of other CC chemokines. CCL16 interacts with cell surface chemokine receptors such as CCR1, CCR2, CCR5, and CCR8 to exert its effects. High levels of CCL16 are found in human blood plasma. CCL16 may be involved in the trafficking of eosinophils, as it binds to H4 receptors expressed by eosinophils and mast cells. Additionally, CCL16 has been shown to suppress the rapid proliferation of myeloid progenitor cells.
CCL16 is also known as CKb12, HCC-4, ILINCK, LCC-1, LEC, LMC, Mtn-1, NCC-4, NCC4, SCYA16, SCYL4.
