CCL15
Description
The CCL15 (C-C motif chemokine ligand 15) is a protein-coding gene located on chromosome 17.
Chemokine (C-C motif) ligand 15 (CCL15) is a small cytokine belonging to the CC chemokine family. It is also known as leukotactin-1, MIP5, and HCC-2. CCL15 is expressed in the liver, small intestine, colon, and certain leukocytes and macrophages of the lung. This chemokine attracts neutrophils, monocytes, and lymphocytes by binding to cell surface chemokine receptors like CCR1 and CCR3. The human CCL15 gene spans four exons and is located on chromosome 17, positioned head-to-tail with the gene for another CC chemokine known as CCL14.
CCL15 primarily attracts T-cells and monocytes, excluding neutrophils, eosinophils, and B-cells. Its main mode of action is through binding to the CC chemokine receptor CCR1, though it can also interact with CCR3. Interestingly, truncated forms of CCL15, specifically CCL15(22-92), CCL15(25-92), and CCL15(29-92), exhibit stronger chemoattractant properties compared to the full-length CCL15.
CCL15 is also known as HCC-2, HMRP-2B, LKN-1, LKN1, MIP-1 delta, MIP-1D, MIP-5, MRP-2B, NCC-3, NCC3, SCYA15, SCYL3, SY15.
Associated Diseases
- cholesterol-ester transfer protein deficiency
- hypertriglyceridemia 2
- thyroid hormone metabolism, abnormal, 2
- sitosterolemia
- homozygous familial hypercholesterolemia
- familial apolipoprotein C-II deficiency
- dilated cardiomyopathy 1I
