CCL14

Description

The CCL14 (C-C motif chemokine ligand 14) is a protein-coding gene located on chromosome 17.

CCL14, also known as HCC-1, is a small cytokine belonging to the CC chemokine family. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids. This mature protein shares 46% amino acid sequence identity with CCL3 and CCL4. CCL14 is expressed in various tissues, including the spleen, bone marrow, liver, muscle, and gut. While it activates monocytes, it does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other CC chemokines.

CCL14 exhibits weak activity on human monocytes, acting through receptors that also bind MIP-1 alpha. It triggers intracellular calcium changes and enzyme release at concentrations of 100-1,000 nM, but does not induce chemotaxis. Notably, CCL14 is inactive on T-lymphocytes, neutrophils, and eosinophils. However, it enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) functions as a chemotactic factor, attracting monocytes, eosinophils, and T-cells, and acts as a ligand for the receptors CCR1, CCR3, and CCR5.

CCL14 is also known as CC-1, CC-3, CKB1, HCC-1, HCC-1(1-74), HCC-1/HCC-3, HCC-3, MCIF, NCC-2, NCC2, SCYA14, SCYL2, SY14.

Associated Diseases

WES Whole Exome Sequencing