CCL13

Description

The CCL13 (C-C motif chemokine ligand 13) is a protein-coding gene located on chromosome 17.

CCL13 is a small cytokine belonging to the CC chemokine family. Its gene is located on human chromosome 17 within a large cluster of other CC chemokines. CCL13 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5. Activity of this chemokine has been implicated in allergic reactions such as asthma. CCL13 can be induced by the inflammatory cytokines interleukin-1 and TNF-α.

CCL13 is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. It signals through CCR2B and CCR3 receptors and plays a role in the accumulation of leukocytes in both allergic and non-allergic inflammation. CCL13 may be involved in the recruitment of monocytes into the arterial wall during the development of atherosclerosis and may play a role in the attraction of monocytes to tissues chronically exposed to exogenous pathogens.

CCL13 is also known as CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1.

Associated Diseases

• major depressive disorder
• ovarian cancer
• C1 inhibitor deficiency
• severe combined immunodeficiency due to CARD11 deficiency
• CIDEC-related familial partial lipodystrophy
• autosomal systemic lupus erythematosus type 16
• hyper-IgE recurrent infection syndrome 5, autosomal recessive
• neutrophil immunodeficiency syndrome
• severe combined immunodeficiency due to IKK2 deficiency
• T-B+ severe combined immunodeficiency due to JAK3 deficiency