CCL11
Description
The CCL11 (C-C motif chemokine ligand 11) is a protein-coding gene located on chromosome 17.
CCL11, also known as eotaxin-1, is a protein encoded by the CCL11 gene on chromosome 17. It belongs to the CC chemokine family and selectively recruits eosinophils by inducing their chemotaxis, playing a crucial role in allergic responses. CCL11 binds to the chemokine receptor CCR3, but also interacts with CCR2 and CCR5. While CCL11 has high selectivity for CCR3, it is inactive on neutrophils and monocytes which lack CCR3 expression. Elevated CCL11 levels in blood plasma are associated with aging in both mice and humans. Exposure of young mice to CCL11 or the blood plasma of older mice reduces neurogenesis and cognitive performance on tasks dependent on the hippocampus. Higher plasma concentrations of CCL11 are observed in current cannabis users compared to past users and those who have never used.
CCL11 is also known as SCYA11.
