CCL1

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Description

The CCL1 (C-C motif chemokine ligand 1) is a protein-coding gene located on chromosome 17.

Chemokine (C-C motif) ligand 1 (CCL1) is also known as small inducible cytokine A1 and I-309 in humans. CCL1 is a small glycoprotein that belongs to the CC chemokine family. CCL1 is encoded by CCL1 gene which is one of the several chemokine genes clustered on the chromosome 17q11.2-q12 in humans. It is expressed by specifically activated T cells upon secondary stimulation. The homologous mouse gene is termed Tca-3. CCL is the first human CCL chemokine that was identified by molecular cloning during searching for genes expressed by T cells. CCL1 is a small glycoprotein with a molecular weight of approximately 15-16 kDa. CCL1 is secreted by activated monocytes/macrophages, T lymphocytes and endothelial cells. CCL1 binds to the chemokine receptor CCR8 and induces Ca2+ influx, chemotaxis and regulate apoptosis. CCR8 is constitutively expressed in monocytes/macrophages, Th2, and regulatory T lymphocytes.

CCL1 is also known as I-309, P500, SCYA1, SISe, TCA3.

Associated Diseases

• C1 inhibitor deficiency
• severe combined immunodeficiency due to CARD11 deficiency
• CIDEC-related familial partial lipodystrophy
• autosomal systemic lupus erythematosus type 16
• hyper-IgE recurrent infection syndrome 5, autosomal recessive
• neutrophil immunodeficiency syndrome
• severe combined immunodeficiency due to IKK2 deficiency
• T-B+ severe combined immunodeficiency due to JAK3 deficiency