CCKBR
Description
The CCKBR (cholecystokinin B receptor) is a protein-coding gene located on chromosome 11.
The cholecystokinin B receptor, also known as CCKBR or CCK2, is a protein encoded by the CCKBR gene in humans. This gene encodes a G protein-coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, with high affinity for both sulfated and nonsulfated CCK analogs, primarily found in the central nervous system and gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors.
CNS effects CCK receptors significantly influence neurotransmission in the brain, regulating anxiety, feeding, and locomotion. CCK-B expression may correlate with anxiety and depression phenotypes in humans. CCK-B receptors have a complex regulation of dopamine activity in the brain. CCK-B activation appears to have a general inhibitory action on dopamine activity in the brain, opposing the dopamine-enhancing effects of CCK-A. However, the effects of CCK-B on dopamine activity vary depending on location. CCK-B antagonism enhances dopamine release in rat striatum. Activation enhances GABA release in rat anterior nucleus accumbens.
CCKBR is also known as CCK-2R, CCK-B, CCK2R, GASR.
