CCHCR1
Description
The CCHCR1 (coiled-coil alpha-helical rod protein 1) is a protein-coding gene located on chromosome 6.
CCHCR1, also known as Coiled-coil alpha-helical rod protein 1, is a protein encoded by the CCHCR1 gene in humans. The gene is located at 6p21.33 and has homologs in tetrapods and orthologs throughout vertebrates. The protein is primarily composed of alpha-helices, coils, and beta sheets. It may be a regulator of keratinocyte proliferation or differentiation. CCHCR1 has been shown to interact with proteins including POLR2C, KRT17, TOP3B, Steroidogenic acute regulatory protein, TRAF4, HLA-C, TCF19, SNX29, EEF1D, and EEF1B2. Certain CCHCR1 polymorphisms may be associated with psoriasis, as they can lead to upregulation of the expression of cytokeratins 6, 16, and 17 and changes in expression in other genes associated with terminal differentiation and the formation of the cornified cell envelope. Defective functioning of CCHCR1 may contribute to abnormal keratinocyte proliferation, a key characteristic of psoriasis.
CCHCR1 is also known as C6orf18, HCR, SBP, pg8.
