CCDC25
Description
The CCDC25 (coiled-coil domain containing 25) is a protein-coding gene located on chromosome 8.
CCDC25 is a transmembrane receptor that detects neutrophil extracellular traps (NETs), which are mainly composed of DNA fibers released by neutrophils to bind pathogens during inflammation. CCDC25 binds specifically to the 8-OHdG-enriched DNA present in NETs, recruiting ILK (integrin-linked kinase) and activating the ILK-PARVB pathway. This pathway triggers cytoskeleton rearrangement and directional cell migration, promoting cell motility. In cancer, CCDC25 senses NETs and promotes the migration of tumor cells, contributing to cancer metastasis.
CCDC25 is also known as -.
Associated Diseases
- cancer
- retinitis pigmentosa
- nonpapillary renal cell carcinoma
- severe early-childhood-onset retinal dystrophy
- isolated aniridia
- snowflake vitreoretinal degeneration
- birdshot chorioretinopathy
- Coats disease
- X-linked retinal dysplasia
- Wagner disease
- coloboma, ocular, autosomal dominant
