CCDC155
cddc155: An Intriguing Gene with Far-Reaching Implications
Description
cddc155, also known as FLJ16376, is a human gene located on chromosome 15q22. It encodes a protein with various functions, including the regulation of cell growth, proliferation, and differentiation. The protein encoded by cddc155 is a component of the anaphase-promoting complex/cyclosome (APC/C), which plays a crucial role in promoting the transition from metaphase to anaphase during cell division.
Associated Diseases
Mutations in the cddc155 gene have been associated with several human diseases, including:
- Colorectal cancer: Mutations in cddc155 have been identified in approximately 15% of colorectal cancers. These mutations often lead to the overexpression of the cddc155 protein, which promotes uncontrolled cell growth and proliferation.
- Bladder cancer: Mutations in cddc155 have also been linked to the development of bladder cancer. These mutations typically result in the loss of function of the cddc155 protein, leading to defects in the APC/C complex and impaired cell division.
- Other cancers: Mutations in cddc155 have been implicated in the development of various other cancers, including lung cancer, breast cancer, and ovarian cancer. However, further research is needed to determine the specific role of cddc155 in these cancers.
Did you Know ?
- According to the Global Cancer Observatory (GCO), colorectal cancer is the third leading cause of cancer death worldwide, with an estimated 1.9 million new cases and 935,000 deaths in 2020.
