CCDC105
Title: CDCC105: A Comprehensive Guide to a Key Regulator in Cell Growth and Beyond
Description:
CDCC105, an essential protein in maintaining cellular homeostasis, plays a crucial role in various cellular processes, including cell cycle progression, DNA damage response, and apoptosis. This blog post provides an in-depth overview of CDCC105, exploring its functions, its involvement in diseases, and the latest research findings on this vital protein.
Functions of CDCC105:
CDCC105 is a central component of the anaphase-promoting complex or cyclosome (APC/C), an E3 ubiquitin ligase that targets specific proteins for degradation. Its primary function is to regulate cell cycle progression through the targeted degradation of mitotic cyclins, allowing cells to transition smoothly from mitosis into the subsequent cell cycle phase.
Associated Diseases:
Dysregulation of CDCC105 has been linked to various human diseases, including:
- Cancer: Abnormal CDCC105 expression or function can contribute to the uncontrolled proliferation and survival of cancer cells, leading to tumorigenesis.
- Neurodegenerative diseases: Impaired CDCC105 activity has been implicated in the pathogenesis of Alzheimer's disease and Parkinson's disease.
- Developmental disorders: Mutations in CDCC105 have been associated with developmental disorders such as microcephaly and corpus callosum agenesis.
Did you Know ?
- A genome-wide association study identified a common variant in CDCC105 that is significantly associated with an increased risk of breast cancer.
