CCAR1
Description
The CCAR1 (cell division cycle and apoptosis regulator 1) is a protein-coding gene located on chromosome 10.
CCAR1 (Cell division cycle and apoptosis regulator protein 1) is a protein encoded by the CCAR1 gene in humans. It is involved in regulating cell division and apoptosis.
CCAR1 associates with Mediator and p160 coactivator complexes, acting as an intermediary to transmit regulatory signals from upstream transcriptional activators to the core promoter. It is recruited to nuclear receptor target genes in response to hormone stimulation and functions as a p53 coactivator, suggesting a significant role in transcriptional regulation. CCAR1 may participate in apoptosis signaling in the presence of the retinoid CD437, involving the sequestration of 14-3-3 proteins and altered expression of cell cycle genes like MYC, CCNB1, and CDKN1A. CCAR1 contributes to cell cycle progression and proliferation. In conjunction with CALCOCO1, it enhances GATA1 and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation. CCAR1 can act as both a coactivator and corepressor of AR-mediated transcription, facilitating chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 interactions on chromatin and promoting MED1 and RNA polymerase II recruitment to AR-binding sites. This suggests a potential role in prostate cancer cell growth and tumorigenesis.
CCAR1 is also known as -.
