CBX5
Description
The CBX5 (chromobox 5) is a protein-coding gene located on chromosome 12.
CBX5 is a human gene that encodes a chromatin protein called Chromobox protein homolog 5. This protein plays a role in the regulation of gene expression by binding to specific regions of DNA and influencing the accessibility of genes to transcription factors.
CBX5, a component of heterochromatin, binds to histone H3 tails methylated at lysine 9 (H3K9me), leading to epigenetic repression. However, CBX5 is excluded from chromatin when tyrosine 41 of histone H3 is phosphorylated (H3Y41ph). CBX5 interacts with the lamin-B receptor (LBR), which helps attach heterochromatin to the inner nuclear membrane. CBX5 is also involved in the formation of functional kinetochores by interacting with MIS12 complex proteins.
CBX5 is also known as HEL25, HP1, HP1A, HP1alpha.
