CBR4
Description
The CBR4 (carbonyl reductase 4) is a protein-coding gene located on chromosome 4.
CBR4 is a human gene that encodes a protein involved in mitochondrial fatty acid biosynthesis and detoxification. It forms part of the KAR complex, a key enzyme in the mtFAS pathway. CBR4 also exhibits quinone reductase activity, potentially protecting cells against the damaging effects of quinones.
CBR4, also known as carbonyl reductase family member 4, is a component of the KAR (3-ketoacyl-[acyl carrier protein] reductase) complex, which is part of the mitochondrial fatty acid synthase (mtFAS). It functions as the beta-subunit of the KAR complex, responsible for the 3-ketoacyl-ACP reductase activity. This enzyme reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner, participating in mitochondrial fatty acid biosynthesis. CBR4 can also form homotetramers with NADPH-dependent quinone reductase activity, potentially playing a role in protection against the cytotoxicity of exogenous quinones. As a heterotetramer, CBR4 can reduce various quinones, including 9,10-phenanthrenequinone and 1,4-benzoquinone.
CBR4 is also known as SDR45C1.
Associated Diseases
- Gorham-Stout disease
- dacryocystitis-osteopoikilosis syndrome
- melorheostosis
- 12q14 microdeletion syndrome
- pyknoachondrogenesis
- osteomesopyknosis
- osteosclerosis-ichthyosis-premature ovarian failure syndrome
- hyperostosis corticalis generalisata
- gnathodiaphyseal dysplasia
- dentin dysplasia-sclerotic bones syndrome
