CBR3
Description
The CBR3 (carbonyl reductase 3) is a protein-coding gene located on chromosome 21.
Carbonyl reductase [NADPH] 3 is an enzyme encoded by the CBR3 gene in humans. It catalyzes the reduction of various biologically and pharmacologically active carbonyl compounds into their corresponding alcohols. This enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.
CBR3 catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols. It has low NADPH-dependent oxidoreductase activity. CBR3 acts on several orthoquinones, as well as non-quinone compounds like isatin and the anticancer drug oracin. Its best substrate is 1,2-naphthoquinone, suggesting a role in protecting against the cytotoxicity of exogenous quinones. CBR3 exhibits activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3, except isatin, has been identified.
CBR3 is also known as HEL-S-25, SDR21C2, hCBR3.
