CATSPERB
Mast Cell Activation Syndrome: An Overview
Description
Mast cell activation syndrome (MCAS) is a condition characterized by the excessive release of inflammatory mediators from mast cells, specialized immune cells that are found throughout the body. When mast cells are activated, they release a variety of substances, including histamine, tryptase, and prostaglandins. These substances can cause a wide range of symptoms, including:
- Skin problems (e.g., hives, itching, flushing)
- Gastrointestinal problems (e.g., abdominal pain, diarrhea, nausea)
- Respiratory problems (e.g., wheezing, shortness of breath)
- Cardiovascular problems (e.g., palpitations, chest pain)
- Neurological problems (e.g., headache, fatigue, dizziness)
MCAS can be triggered by a variety of factors, including:
- Allergens
- Infections
- Certain medications
- Stress
Associated Diseases
MCAS has been associated with a number of other conditions, including:
- Autoimmune diseases (e.g., lupus, rheumatoid arthritis)
- Chronic fatigue syndrome
- Fibromyalgia
- Irritable bowel syndrome
- Autism spectrum disorder
Did you Know ?
- MCAS is estimated to affect 1 in 10,000 people. However, it is likely that the true prevalence is much higher, as many cases are undiagnosed.
