CATSPER3
CatSper3: The Essential Ion Channel for Male Fertility
Description
CatSper3 (CatSper ion channel auxiliary subunit 3) is a protein encoded by the CATSPER3 gene in humans. It forms an integral part of the CatSper ion channel, a multi-subunit protein complex located in the plasma membrane of sperm cells. The CatSper channel is essential for sperm motility, the ability of sperm to swim and reach the egg for fertilization.
CatSper3 is specifically involved in the regulation of sperm calcium influx, which is crucial for initiating and maintaining the flagellar beating pattern necessary for sperm locomotion. The channel allows the influx of calcium ions into the sperm cell in response to specific stimuli, such as progesterone from the egg.
Associated Diseases
Mutations or alterations in the CATSPER3 gene can lead to male infertility due to impaired sperm motility. In humans, CatSper3-related infertility is characterized by:
- Asthenozoospermia: Reduced sperm motility
- Teratozoospermia: Abnormal sperm morphology
- Oligospermia: Low sperm count
CatSper3 mutations are estimated to account for approximately 5-10% of cases of male infertility.
Did you Know ?
- A study published in the journal Nature Genetics found that variations in the CATSPER3 gene are associated with a 40% reduction in sperm motility.
