CASP2
Description
The CASP2 (caspase 2) is a protein-coding gene located on chromosome 7.
CASP2 is an enzyme encoded by the CASP2 gene in humans. It is highly conserved across various animal species, including mammals, birds, reptiles, amphibians, and fish. Caspases are involved in the execution phase of apoptosis, a process of programmed cell death. CASP2 is activated by a variety of apoptotic stimuli and cleaves other proteins. It is part of the Ich-1 subfamily of cysteine proteases, a group of enzymes that cleave proteins specifically after aspartic acid residues.
CASP2 is involved in the activation cascade of caspases, a group of enzymes responsible for the execution of apoptosis, the programmed death of cells. CASP2 may function by activating proteins required for cell death or by inactivating proteins that promote cell survival. It forms a complex called the PIDDosome with PIDD1 and CRADD, which is triggered by genotoxic stress and leads to the activation of CASP2 and subsequent apoptosis.
CASP2 is also known as CASP-2, ICH1, MRT80, NEDD-2, NEDD2, PPP1R57.
