CASC5
Caspase-5 (CASC5)
Description
Caspase-5 (CASC5) is a protease enzyme that plays a central role in the apoptotic, or programmed cell death, pathway. It belongs to the caspase family of enzymes, which are responsible for executing the final steps of apoptosis. Caspase-5 specifically functions as an initiator caspase, triggering the activation of other caspases and the subsequent dismantling of the cell.
Associated Diseases
Dysregulation of caspase-5 activity has been implicated in various diseases, including:
- Cancer: Caspase-5 deficiency or inactivation contributes to cancer development by promoting cell survival and inhibiting apoptosis.
- Neurodegenerative disorders: Impaired caspase-5 function has been observed in conditions such as Alzheimer's disease and Parkinson's disease, where it may play a role in neuronal cell death.
- Immune disorders: Dysregulated caspase-5 activity can affect immune cell function, potentially contributing to autoimmune diseases.
Did you Know ?
Approximately 5-10% of all human proteins are estimated to be involved in the apoptotic pathway, with caspase-5 being a key player.
