CASC10

Headline: The Enigma of CASC10: Exploring Its Role in Health, Disease, and Aging

Introduction: CASC10, an enigmatic protein, has recently gained scientific intrigue for its multifaceted roles in various biological processes. Its involvement in diseases and aging has made it a promising target for therapeutic interventions.

Description: CASC10, a member of the Cancer Susceptibility Candidate 10 gene family, is located on human chromosome 10q23.33. It encodes a ubiquitously expressed protein consisting of 637 amino acids with diverse functions, including DNA repair, apoptosis, cell cycle regulation, and maintenance of genomic stability.

Associated Diseases: Dysregulation of CASC10 has been implicated in several diseases:

Cancer: CASC10 overexpression is associated with increased tumor growth, migration, and invasion. It has been found in lung, breast, liver, and other cancers.
Neurodegenerative Diseases: Reduced CASC10 expression is linked to neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, where its deficiency impairs neuron survival and function.
Cardiovascular Diseases: Alterations in CASC10 levels have been associated with heart failure, atherosclerosis, and hypertension, suggesting a role in cardiovascular health.

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Studies have shown that individuals with low CASC10 levels are at an increased risk of developing cancer, with a 40% higher likelihood of tumor formation.

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Additional Information on Latest Research: Recent research has shed light on the molecular mechanisms underlying CASC10's functions:

DNA Repair: CASC10 forms a complex with XRCC1 and DNA polymerase β to facilitate DNA repair pathways, ensuring genome integrity.
Cell Cycle Regulation: CASC10 interacts with cyclin-dependent kinases (CDKs) to control cell cycle progression, promoting cell proliferation and differentiation.
Aging: Studies suggest that CASC10 levels decline with age, contributing to age-related cellular dysfunction and the development of chronic diseases.

Conclusion: CASC10, a multifunctional protein with diverse biological roles, has emerged as a promising target for understanding and treating various diseases. Continued research into its molecular mechanisms and therapeutic potential is crucial to harness its utility in improving human health and longevity.

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