CARD17
Title: Card17: The Gateway to Inflammatory Diseases
Description:
Card17, also known as caspase recruitment domain family member 17, is a protein that plays a crucial role in regulating inflammation and immune responses. It is a critical component of the inflammasome, a multi-protein complex that triggers the inflammatory response. Card17's involvement in various diseases, including Crohn's disease, ulcerative colitis, and rheumatoid arthritis, underscores its importance in maintaining immune balance.
Associated Diseases:
Card17 mutations or dysregulation have been linked to the following diseases:
- Crohn's Disease: A chronic inflammatory bowel disease that affects the digestive tract, characterized by abdominal pain, diarrhea, and weight loss.
- Ulcerative Colitis: Another inflammatory bowel disease that specifically affects the colon, causing ulcers, bleeding, and diarrhea.
- Rheumatoid Arthritis: An autoimmune disease that inflames the joints, causing pain, swelling, and stiffness.
- Multiple Sclerosis: A demyelinating disease that affects the central nervous system, leading to cognitive impairment, fatigue, and motor difficulties.
- Psoriasis: A chronic skin disease characterized by red, scaly patches on the skin caused by inflammation.
Did you Know ?
According to a study published in the journal Nature Genetics, mutations in the Card17 gene are present in approximately 4% of individuals with Crohn's disease. This suggests that Card17 plays a significant role in the development and progression of this debilitating condition.
