CARD16
Description
The CARD16 (caspase recruitment domain family member 16) is a protein-coding gene located on chromosome 11.
CARD16 is a caspase inhibitor that regulates the activation of procaspase-1 (CASP1). It plays a role in controlling the maturation and release of pro-interleukin-1 beta (IL1B) during inflammation. CARD16 inhibits the release of IL1B in response to lipopolysaccharide (LPS) in monocytes. It also activates NF-kappa-B, a key transcription factor involved in the pro-inflammatory cytokine response. CARD16 can inhibit CASP1-mediated neuronal cell death, as well as cell death triggered by TNF-alpha, hypoxia, UV radiation, and staurosporine. However, it does not prevent ER stress-mediated cell death. CARD16 achieves its inhibitory effects by preventing the activation of caspases CASP1 and CASP4, possibly by blocking the interaction between CASP1 and RIPK2.
CARD16 is also known as COP, COP1, LLID-114769, PSEUDO-ICE.
