Carbamezapine

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Carbamezapine: Understanding its Impact, Recognizing Problems, and Ways to Improve

Carbamazepine is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy.Occasionally, it is also used to treat bipolar disorder.

Impact of Gene Variant

Genetic variation of the ATP-binding cassette subfamily B, member 1 (ABCB1) gene, a drug efflux transporter, may infer treatment resistance by decreasing gastrointestinal absorption and preventing Carbamazepine entry into the brain.Variant alleles of the ABCB1 gene were significantly associated with Carbamazepine resistance.Carbamazepine stimulates transcriptional upregulation of CYP3A4 and other genes involved in its own metabolism.

Ways to Recognize Problems

• Common side effects include dizziness, drowsiness, nausea, vomiting, and unsteadiness.
• Serious side effects may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
• Some people may have thoughts about suicide while taking this medicine.