CAPRIN2
Description
The CAPRIN2 (caprin family member 2) is a protein-coding gene located on chromosome 12.
CAPRIN2, also known as CAPRIN2, is a human gene. The protein encoded by this gene may be involved in the transitioning of erythroblasts from a highly proliferative state to a terminal phase of differentiation. High-level expression of the encoded protein can lead to apoptosis. Several transcript variants encoding different isoforms have been found for this gene.
CAPRIN2 promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway. It also facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during the G2/M stage of the cell cycle, potentially potentiating cells for Wnt signaling. CAPRIN2 may regulate the transport and translation of mRNAs, modulating the expression of proteins involved in synaptic plasticity in neurons. Furthermore, CAPRIN2 is involved in regulating growth as erythroblasts transition from a highly proliferative state to their terminal phase of differentiation. CAPRIN2 may also be involved in apoptosis.
CAPRIN2 is also known as C1QDC1, EEG-1, EEG1, RNG140.
