CAPN9
Description
The CAPN9 (calpain 9) is a protein-coding gene located on chromosome 1.
Calpain-9 is a protein encoded by the CAPN9 gene in humans. It belongs to the calpain family, a group of calcium-dependent cysteine proteases that are widespread and well-conserved. Calpains are heterodimers, composed of an invariant small subunit and variable large subunits. The large subunit contains a cysteine protease domain, while both subunits have calcium-binding domains. Calpains have been linked to neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by CAPN9 is predominantly expressed in the stomach and small intestine, suggesting specialized functions within the digestive tract. This gene is believed to be associated with gastric cancer. Multiple transcript variants encoding different isoforms have been identified for this gene.
CAPN9 is also known as GC36, nCL-4.
