CAMKK1
Description
The CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1) is a protein-coding gene located on chromosome 17.
CAMKK1, encoded by the CAMKK1 gene, is a serine/threonine protein kinase involved in the calcium/calmodulin-dependent (CaM) kinase cascade. It belongs to the Ca(2+)/calmodulin-dependent protein kinase (CAMK) subfamily. This gene has three transcript variants that encode two distinct isoforms. CAMKK1 plays a role in calcium signaling and cell survival.
CAMKK1 is a calcium/calmodulin-dependent protein kinase that plays a crucial role in a calcium-triggered signaling cascade. This kinase phosphorylates several other kinases, including CAMK1, CAMK1D, CAMK1G, and CAMK4, contributing to various cellular processes. CAMKK1 is also involved in regulating cell apoptosis. It promotes cell survival by phosphorylating AKT1/PKB, which in turn inhibits the pro-apoptotic protein BAD/Bcl2-antagonist of cell death.
CAMKK1 is also known as CAMKKA.
