CAMK2N1
Description
The CAMK2N1 (calcium/calmodulin dependent protein kinase II inhibitor 1) is a protein-coding gene located on chromosome 1.
CAMK2N1 is a potent and specific inhibitor of CaM-kinase II (CAMK2). It plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear. It modulates blood pressure and vascular reactivity via regulation of CAMK2 activity, as well as regulates left ventricular mass. It mediates the NLRP3 inflammasome in cardiomyocytes by inhibiting the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction. It negatively impacts insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling.
CAMK2N1 is also known as PRO1489.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- type 2 diabetes mellitus
