CALU
Description
The CALU (calumenin) is a protein-coding gene located on chromosome 7.
Calumenin is a protein in humans encoded by the CALU gene. It's a calcium-binding protein found within the endoplasmic reticulum (ER) and plays a role in processes like protein folding and sorting within the ER. It belongs to the CERC family of EF-hand proteins, also found in the ER and Golgi apparatus, which includes Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene produces a protein with 315 amino acids, containing 6 EF-hand motifs, a potential N-glycosylation site, and an ER retention signal at its C-terminus. The human and mouse CALU proteins are highly similar (98% identical). CALU mRNA is found in various human tissues and is located on chromosome 7 at position 7q32.
Calumenin plays a role in regulating the vitamin K-dependent carboxylation of several glutamate residues located at the N-terminus of proteins. It appears to suppress the activity of gamma-carboxylase (GGCX). Calumenin can bind up to seven calcium ions, but with a relatively low affinity.
CALU is also known as -.
Associated Diseases
- Alzheimer disease
- lysosomal storage disease
- multiple sclerosis
- Parkinson disease
- esophageal cancer
- cancer
- Joubert syndrome
