CALCB
Description
The CALCB (calcitonin related polypeptide beta) is a protein-coding gene located on chromosome 11.
Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides, which includes calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin), and calcitonin-receptor-stimulating peptide. Calcitonin is mainly produced by thyroid C cells, while CGRP is secreted and stored in the nervous system. In humans, CGRP exists in two forms: CGRP alpha (α-CGRP or CGRP I), and CGRP beta (β-CGRP or CGRP II). α-CGRP is a 37-amino acid neuropeptide and is formed by alternative splicing of the calcitonin/CGRP gene located on chromosome 11. β-CGRP is less studied. In humans, β-CGRP differs from α-CGRP by three amino acids and is encoded in a separate, nearby gene. The CGRP family includes calcitonin (CT), adrenomedullin (AM), and amylin (AMY). CGRP is produced in both peripheral and central neurons. It is a potent peptide vasodilator and can function in the transmission of nociception. In the spinal cord, the function and expression of CGRP may differ depending on the location of synthesis.
CALCB is also known as CALC2, CGRP-II, CGRP2.
Associated Diseases
- migraine disorder
- diverticulitis
- thyroid gland adenocarcinoma
- familial atrial fibrillation
- Brugada syndrome
- diabetic polyneuropathy
- sinoatrial node dysfunction and deafness
- long QT syndrome 5
