CADPS2
Description
The CADPS2 (calcium dependent secretion activator 2) is a protein-coding gene located on chromosome 7.
CADPS2 (Calcium-dependent secretion activator 2) is a protein encoded by the CADPS2 gene in humans. It belongs to the CAPS (calcium-dependent activator of secretion) protein family, which are calcium-binding proteins regulating exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. CADPS2 interacts with brain-derived neurotrophic factor. CADPS2 has been linked to autism and is located within the 7q autism susceptibility locus (AUTS1). A knockout mouse model of CADPS2 exhibits autistic-like characteristics. Two large genomic studies have linked CADPS2 to human and mouse brain structure.
CADPS2 is a calcium-binding protein that plays a critical role in the release of neurotransmitters and neuropeptides from vesicles. It likely functions before the fusion of these vesicles, contributing to the formation or maintenance of mature secretory vesicles. CADPS2 regulates the release of neurotrophins from granule cells, influencing cell differentiation and survival during the development of the cerebellum. It may specifically facilitate the calcium-dependent release of large dense-core vesicles (DCVs) and other dense-core vesicles.
CADPS2 is also known as CAPS2.
