CADPS
Description
The CADPS (calcium dependent secretion activator) is a protein-coding gene located on chromosome 3.
CADPS (Calcium-dependent secretion activator 1) is a protein encoded by the CADPS gene in humans. It is a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for calcium-regulated exocytosis of secretory vesicles. CADPS acts at a stage following ATP-dependent priming, which involves the synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing at this locus leads to three variants encoding distinct isoforms.
CADPS is a calcium-binding protein crucial for the release of neurotransmitters and neuropeptides from vesicles. It likely plays a role before the actual fusion of vesicles with the cell membrane, potentially influencing the formation or maintenance of mature secretory vesicles. CADPS is involved in regulating the storage of catecholamines within dense-core vesicles (DCVs). Specifically, CADPS might mediate the release of contents from large DCVs and other dense-core vesicles by interacting with phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) at a step preceding fusion, after ATP-dependent priming. This suggests its involvement in the fusion process of DCVs with the cell membrane. While CADPS is primarily associated with DCVs, it may also play a role in the release of contents from small clear synaptic vesicles (SVs), although the specific mechanism and its connection to calcium signaling in this context remain unclear.
CADPS is also known as CADPS1, CAPS, CAPS1, UNC-31.
