CACTIN
Description
The CACTIN (cactin, spliceosome C complex subunit) is a protein-coding gene located on chromosome 19.
CACTIN, also known as renal carcinoma antigen NY-REN-24, is a protein encoded by the CACTIN gene in humans. Originally identified in Drosophila, the CACTIN gene product is involved in regulating the innate immune system. It acts as a negative regulator of the Toll-like receptor, Interferon regulatory factor (IRF) and the canonical NF-kappa-B signaling pathways. The full-length cactin protein is 3,150 bp long with an N-terminus from 356–547 residues and a domain in the C-terminal 731–855 residues. This protein is found in many organs and tissues of all vertebrates, and has also been found in plants, protist, and fungi. Cactin is most concentrated in the testis of males and in the spleen. In these areas, the cactin gene enables RNA binding activity. Cactin is also involved in cellular response from cytokines and negative signal transduction (negative feedback loops). In plants, cactin is associated with SR proteins localized in nuclear speckles.
CACTIN plays a role in pre-mRNA splicing by facilitating the removal of specific introns. It is essential for the splicing of CDCA5/Sororin, a protein involved in the regulation of sister chromatid cohesion. CACTIN also participates in the regulation of the innate immune response, acting as a negative regulator of the Toll-like receptor, interferon-regulatory factor (IRF), and canonical NF-kappa-B signaling pathways. This protein contributes to the control of NF-kappa-B target gene activation in response to endogenous pro-inflammatory stimuli.
CACTIN is also known as C19orf29, NY-REN-24, fSAPc.
