CACNG4
Description
The CACNG4 (calcium voltage-gated channel auxiliary subunit gamma 4) is a protein-coding gene located on chromosome 17.
CACNG4, the gene encoding the voltage-dependent calcium channel gamma-4 subunit, plays a role in the regulation of calcium channels. It is one of several gamma subunit proteins and is thought to stabilize the calcium channel in an inactive state. CACNG4 is an integral membrane protein and is part of the neuronal calcium channel gamma subunit gene subfamily within the PMP-22/EMP/MP20 family. It is located in a cluster with two similar gamma subunit-encoding genes.
CACNG4 regulates the activity of L-type calcium channels containing the CACNA1C pore-forming subunit. It also regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. CACNG4 promotes AMPAR targeting to the cell membrane and synapses, and modulates their gating properties by slowing activation, deactivation, and desensitization rates, and mediating resensitization.
CACNG4 is also known as -.
